Pharmacokinetics of piperacillin-tazobactam in anuric intensive care patients during continuous venovenous hemodialysis.

نویسندگان

  • Silke C Mueller
  • Jolanta Majcher-Peszynska
  • Heiko Hickstein
  • Astrid Francke
  • Annette Pertschy
  • Martin Schulz
  • Ralf Mundkowski
  • Bernd Drewelow
چکیده

The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination half-life of piperacillin was 4.3 +/- 1.2 h, and that of tazobactam was 5.6 +/- 1.3 h. The contribution of CVVHD to the overall elimination was relevant (>25%) for both drugs.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 5  شماره 

صفحات  -

تاریخ انتشار 2002